作者
Nezam Altorok, Patrick Coit, Travis Hughes, Kristi A Koelsch, Donald U Stone, Astrid Rasmussen, Lida Radfar, R Hal Scofield, Kathy L Sivils, A Darise Farris, Amr H Sawalha
发表日期
2014/3
期刊
Arthritis & rheumatology
卷号
66
期号
3
页码范围
731-739
简介
Objective
Primary Sjögren's syndrome (SS) is a systemic autoimmune disease with incompletely understood etiology. This study was undertaken to investigate the role of epigenetic dysregulation in the pathogenesis of primary SS.
Methods
A genome‐wide DNA methylation study was performed in naive CD4+ T cells from 11 patients with primary SS compared to age‐, sex‐, and ethnicity‐matched healthy controls. Cytosine methylation was quantified using the Illumina Infinium HumanMethylation450 BeadChip array, and the data were validated using bisulfite sequencing.
Results
Genome‐wide analyses identified 553 hypomethylated CpG sites and 200 hypermethylated CpG sites in naive CD4+ T cells from patients with primary SS as compared to healthy controls, representing 311 hypomethylated and 115 hypermethylated gene regions. The hypomethylated genes in patients with primary SS included LTA …
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