作者
Georgios K Efthimiadis, Georgios Giannakoulas, Despina G Parcharidou, Efstathios D Pagourelias, Evangelia J Kouidi, Georgios Spanos, Vasileios Kamperidis, Stavros Gavrielides, Haralambos Karvounis, Ioannis Styliadis, Georgios E Parcharidis
发表日期
2011/12/1
期刊
International journal of cardiology
卷号
153
期号
2
页码范围
179-184
出版商
Elsevier
简介
BACKGROUND
Diminished functional capacity is common in hypertrophic cardiomyopathy (HCM), although the underlying mechanisms are complicated. We studied the prevalence of chronotropic incompetence and its relation to exercise intolerance in patients with HCM.
METHODS
Cardiopulmonary exercise testing was performed in 68 patients with HCM (age 44.8±14.6years, 45 males). Chronotropic incompetence was defined by chronotropic index (heart rate reserve)/(220-age-resting heart rate) and exercise capacity was assessed by peak oxygen consumption (peak Vo2).
RESULTS
Chronotropic incompetence was present in 50% of the patients and was associated with higher NYHA class, history of atrial fibrillation, higher fibrosis burden on cardiac MRI, and treatment with β-blockers, amiodarone and warfarin. On univariate analysis, male gender, age, NYHA class, maximal wall thickness, left atrial diameter …
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GK Efthimiadis, G Giannakoulas, DG Parcharidou… - International journal of cardiology, 2011