作者
Jacqueline M Ferguson, Sadie Costello, Holly Elser, Andreas M Neophytou, Sally Picciotto, Debra T Silverman, Ellen A Eisen
发表日期
2020/1/1
期刊
Environmental research
卷号
180
页码范围
108876
出版商
Academic Press
简介
Background
Miners are highly exposed to diesel exhaust emissions from powered equipment. Although biologically plausible, there is little evidence based on quantitative exposure assessment, that long-term diesel exposure increases risk of chronic obstructive pulmonary disease (COPD). To fill this gap, we examined COPD mortality and diesel exhaust exposure in the Diesel Exhaust in Miners Study (DEMS).
Methods
We fit Cox models to estimate hazard ratios (HRs) for COPD mortality and cumulative exposure (μg/m3-years) to respirable elemental carbon (REC), a key metric for diesel exhaust exposure. Separate models were fit for ever-underground and surface-only miners to allow for effect modification. Exposure was lagged by 0, 10 and 15 years. In a secondary analysis, we addressed the healthy worker survivor effect by applying the parametric g-formula to handle time-varying confounding affected by prior …
学术搜索中的文章
JM Ferguson, S Costello, H Elser, AM Neophytou… - Environmental research, 2020