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Objective:

To determine serum thiol-disulfide homeostasis in hyperemesis gravidarum.

Study Design:

Twenty-six pregnant women with hyperemesis gravidarum and 37 healthy pregnant women were included in the study. Native thiol, disulfide and total thiol concentrations were measured with a novel automated method.

Results:

Serum disulfide levels were 15.68±4.41 μmol l− 1 in the hyperemesis gravidarum group and 13.49±2.81 μmol l− 1 in the healthy group (P= 0.031). Native thiol levels were 213.86±26.29 μmol l− 1 in the hyperemesis gravidarum group and 232.18±19.21 μmol l− 1 in healthy group (P= 0.004), and total thiol levels were 245.23±28.58 μmol l− 1 in the hyperemesis gravidarum group and 259.17±19.94 μmol l− 1 in the healthy group (P= 0.038).

Conclusion:

Native and total thiol were deficient in the hyperemesis gravidarum group and this deficiency was correlated with the severity of the disease …