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We prospectively studied 48 patients with either breast cancer (30 patients) or lung cancer (18 patients) to ascertain the relationship between the degree of accumulation of"" Tc-sestamibi and the expression of p-glycoprotein in tumor tissues. During initial presentation (37 patients) or post-therapy evaluation (11 pa tients), the patients underwent contemporaneous"" Tc-sestamibi imaging and biopsy (30 patients) or surgery (18 patients). The interval between surgery/biopsy and imaging varied between 3 and 15 days. All patients had radiologically detectable tumors. Immunohistochemical studies were performed on paraffin sections using a monoclonal antibody, JSB-1, developed against the internal epitope of p-glycoprotein. Tumor-to-background ratios were correlated with the level of p-glycoprotein expression determined by ¡ mmunohistochemical studies. Our results showed an inverse correla …