作者
Michael A Gillette, Shankha Satpathy, Song Cao, Saravana M Dhanasekaran, Suhas V Vasaikar, Karsten Krug, Francesca Petralia, Yize Li, Wen-Wei Liang, Boris Reva, Azra Krek, Jiayi Ji, Xiaoyu Song, Wenke Liu, Runyu Hong, Lijun Yao, Lili Blumenberg, Sara R Savage, Michael C Wendl, Bo Wen, Kai Li, Lauren C Tang, Melanie A MacMullan, Shayan C Avanessian, M Harry Kane, Chelsea J Newton, MacIntosh Cornwell, Ramani B Kothadia, Weiping Ma, Seungyeul Yoo, Rahul Mannan, Pankaj Vats, Chandan Kumar-Sinha, Emily A Kawaler, Tatiana Omelchenko, Antonio Colaprico, Yifat Geffen, Yosef E Maruvka, Felipe da Veiga Leprevost, Maciej Wiznerowicz, Zeynep H Gümüş, Rajwanth R Veluswamy, Galen Hostetter, David I Heiman, Matthew A Wyczalkowski, Tara Hiltke, Mehdi Mesri, Christopher R Kinsinger, Emily S Boja, Gilbert S Omenn, Arul M Chinnaiyan, Henry Rodriguez, Qing Kay Li, Scott D Jewell, Mathangi Thiagarajan, Gad Getz, Bing Zhang, David Fenyö, Kelly V Ruggles, Marcin P Cieslik, Ana I Robles, Karl R Clauser, Ramaswamy Govindan, Pei Wang, Alexey I Nesvizhskii, Li Ding, DR Mani, Steven A Carr, Alex Webster, Alicia Francis, Alyssa Charamut, Amanda G Paulovich, Amy M Perou, Andrew K Godwin, Andrii Karnuta, Annette Marrero-Oliveras, Barbara Hindenach, Barbara Pruetz, Bartosz Kubisa, Brian J Druker, Chet Birger, Corbin D Jones, Dana R Valley, Daniel C Rohrer, Daniel Cui Zhou, Daniel W Chan, David Chesla, David J Clark, Dmitry Rykunov, Donghui Tan, Elena V Ponomareva, Elizabeth Duffy, Eric J Burks, Eric E Schadt, Erik J Bergstrom, Eugene S Fedorov, Ewa Malc, George D Wilson, Hai-Quan Chen, Halina M Krzystek, Hongwei Liu, Houston Culpepper, Hua Sun, Hui Zhang, Jacob Day, James Suh, Jeffrey R Whiteaker, Jennifer Eschbacher, John McGee, Karen A Ketchum, Karin D Rodland, Karna Robinson, Katherine A Hoadley, Kei Suzuki, Ki Sung Um, Kim Elburn, Liang-Bo Wang, Lijun Chen, Linda Hannick, Liqun Qi, Lori J Sokoll, Małgorzata Wojtyś, Marcin J Domagalski, Marina A Gritsenko, Mary B Beasley, Matthew E Monroe, Matthew J Ellis, Maureen Dyer, Meghan C Burke, Melissa Borucki, Meng-Hong Sun, Michael H Roehrl, Michael J Birrer, Michael Noble, Michael Schnaubelt, Michael Vernon, Michelle Chaikin, Mikhail Krotevich, Munziba Khan, Myvizhi Esai Selvan, Nancy Roche, Nathan J Edwards, Negin Vatanian, Olga Potapova, Pamela Grady, Peter B McGarvey, Piotr Mieczkowski, Pushpa Hariharan, Rashna Madan, Ratna R Thangudu
发表日期
2020/7/9
期刊
Cell
卷号
182
期号
1
页码范围
200-225. e35
出版商
Elsevier
简介
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and acetylproteomics. Multi-omics clustering revealed four subgroups defined by key driver mutations, country, and gender. Proteomic and phosphoproteomic data illuminated biology downstream of copy number aberrations, somatic mutations, and fusions and identified therapeutic vulnerabilities associated with driver events involving KRAS, EGFR, and ALK. Immune subtyping revealed a complex landscape, reinforced the association of STK11 with immune-cold behavior, and underscored a potential immunosuppressive role of neutrophil degranulation. Smoking-associated LUADs showed correlation with …
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