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The IoT scenario is characterized with ultra-dense interworking of billions and billions of devices through a myriad of technologies for the delivery of smart personalized services and applications. The main challenges and distinctive features of this scenario are the large amount of information gathered from the ambient environment and the human body that must be processed mostly in real- or near-real time for the unobtrusive delivery of personalized and often of critical to the user’s well-being services. Smart connectivity in an AAL context relates to the availability of a reliable data channel between devices and between the human and devices and enabling an interface to the cloud/network where information gets personalized. This chapter examines the main research challenges related to the enabling of smart connectivity in an AAL context and proposes a novel approach to scalable and autonomous …