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This paper analyzes county-level firm births across the United States using a spatial count model that permits spatial dependence, cross-correlation among different industry types, and over-dispersion commonly found in empirical count data. Results confirm the presence of spatial autocorrelation (which can arise from agglomeration effects and missing variables), industry-specific over-dispersion, and positive, significant cross-correlations. After controlling for existing-firm counts in 2008 (as an exposure term), parameter estimates and inference suggest that a younger work force and/or clientele (as quantified using each county’s median-age values) is associated with more firm births (in 2009). Higher population densities is associated with more new basic-sector firms, while reducing retail-firm starts. The modeling framework demonstrated here can be adopted for a variety of settings, harnessing very local, detailed …