作者
Wenan Chen, Beth R Larrabee, Inna G Ovsyannikova, Richard B Kennedy, Iana H Haralambieva, Gregory A Poland, Daniel J Schaid
发表日期
2015/7/1
期刊
Genetics
卷号
200
期号
3
页码范围
719-736
出版商
Oxford University Press
简介
Two recently developed fine-mapping methods, CAVIAR and PAINTOR, demonstrate better performance over other fine-mapping methods. They also have the advantage of using only the marginal test statistics and the correlation among SNPs. Both methods leverage the fact that the marginal test statistics asymptotically follow a multivariate normal distribution and are likelihood based. However, their relationship with Bayesian fine mapping, such as BIMBAM, is not clear. In this study, we first show that CAVIAR and BIMBAM are actually approximately equivalent to each other. This leads to a fine-mapping method using marginal test statistics in the Bayesian framework, which we call CAVIAR Bayes factor (CAVIARBF). Another advantage of the Bayesian framework is that it can answer both association and fine-mapping questions. We also used simulations to compare CAVIARBF with other methods under …
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