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In this study, we evaluated the ability of waste shell powder (WSP) and moringa seed powder (MSP) individually or in combination to eliminate dye, heavy metal and resistant bacteria from the industrial wastewater (IWW). The presence of dyes, heavy metals, approximately 7.0 log CFU/ml of aerobic bacteria and 3.0–4.0 log CFU/ml of other pathogens including Escherichia coli, Pseudomonas aeruginosa, Citrobacter freundii, Serratia liquefaciens and Bacillus cereus was evident in IWW of both tannery and textile industries. In addition, depending on the type of bacterial species each bacterium was resistant to as high as 50 ppm of multi-metal (Cr 6+, Cd 2+ and Pb 2+ or its combination) and even multi-drug resistant (amoxicillin, ampicillin, cefixime, ceftazidime, and tazobactam). Combined use of MSP (0.8 gm/100 ml IWW) and WSP (0.2 gm/100 ml IWW) treatment was able to discolor the IWW within 4 h and took 24 h …