作者
Konstantinos Kambas, Akrivi Chrysanthopoulou, Dimitrios Vassilopoulos, Eirini Apostolidou, Panagiotis Skendros, Andreas Girod, Stella Arelaki, Marios Froudarakis, Lydia Nakopoulou, Alexandra Giatromanolaki, Prodromos Sidiropoulos, Maria Koffa, Dimitrios T Boumpas, Konstantinos Ritis, Ioannis Mitroulis
发表日期
2014/10/1
期刊
Annals of the rheumatic diseases
卷号
73
期号
10
页码范围
1854-1863
出版商
BMJ Publishing Group Ltd
简介
Objectives
Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is characterised by neutrophil activation. An elevated prevalence of venous thromboembolic events has been reported in AAV. Because of the critical role of neutrophils in inflammation associated thrombosis, we asked whether neutrophil tissue factor (TF) may be implicated in the thrombotic diathesis in AAV.
Methods
Neutrophils from four patients and sera from 17 patients with ANCA associated vasculitis with active disease and remission were studied. TF expression was assessed by immunoblotting and confocal microscopy. Circulating DNA levels were evaluated. TF expressing microparticles (MPs) were measured by flow cytometry and thrombin–antithrombin complex levels by ELISA.
Results
Peripheral blood neutrophils from four patients with active disease expressed elevated TF levels and released TF expressing neutrophil …
学术搜索中的文章
K Kambas, A Chrysanthopoulou, D Vassilopoulos… - Annals of the rheumatic diseases, 2014