作者
Elizabeth G Atkinson, Shareefa Dalvie, Yakov Pichkar, Allan Kalungi, Lerato Majara, Anne Stevenson, Tamrat Abebe, Dickens Akena, Melkam Alemayehu, Fred K Ashaba, Lukoye Atwoli, Mark Baker, Lori B Chibnik, Nicole Creanza, Mark J Daly, Abebaw Fekadu, Bizu Gelaye, Stella Gichuru, Wilfred E Injera, Roxanne James, Symon M Kariuki, Gabriel Kigen, Nastassja Koen, Karestan C Koenen, Zan Koenig, Edith Kwobah, Joseph Kyebuzibwa, Henry Musinguzi, Rehema M Mwema, Benjamin M Neale, Carter P Newman, Charles RJC Newton, Linnet Ongeri, Sohini Ramachandran, Raj Ramesar, Welelta Shiferaw, Dan J Stein, Rocky E Stroud, Solomon Teferra, Mary T Yohannes, Zukiswa Zingela, Alicia R Martin
发表日期
2022/9/1
期刊
The American Journal of Human Genetics
卷号
109
期号
9
页码范围
1667-1679
出版商
Elsevier
简介
African populations are the most diverse in the world yet are sorely underrepresented in medical genetics research. Here, we examine the structure of African populations using genetic and comprehensive multi-generational ethnolinguistic data from the Neuropsychiatric Genetics of African Populations-Psychosis study (NeuroGAP-Psychosis) consisting of 900 individuals from Ethiopia, Kenya, South Africa, and Uganda. We find that self-reported language classifications meaningfully tag underlying genetic variation that would be missed with consideration of geography alone, highlighting the importance of culture in shaping genetic diversity. Leveraging our uniquely rich multi-generational ethnolinguistic metadata, we track language transmission through the pedigree, observing the disappearance of several languages in our cohort as well as notable shifts in frequency over three generations. We find suggestive …
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EG Atkinson, S Dalvie, Y Pichkar, A Kalungi, L Majara… - The American Journal of Human Genetics, 2022