作者
Julia Lange de Luna, Aayah Nounu, Sonja Neumeyer, Lucy Sinke, Rory Wilson, Fabian Hellbach, Pamela R Matías-García, Thomas Delerue, Juliane Winkelmann, Annette Peters, Barbara Thorand, Marian Beekman, Bastiaan T Heijmans, Eline Slagboom, Christian Gieger, Jakob Linseisen, Melanie Waldenberger
发表日期
2024/2/16
期刊
Clinical Epigenetics
卷号
16
期号
1
页码范围
29
出版商
BioMed Central
简介
Background
Dietary intake of n-3 polyunsaturated fatty acids (PUFA) may have a protective effect on the development of cardiovascular diseases, diabetes, depression and cancer, while a high intake of n-6 PUFA was often reported to be associated with inflammation-related traits. The effect of PUFAs on health outcomes might be mediated by DNA methylation (DNAm). The aim of our study is to identify the impact of PUFA intake on DNAm in the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and the Leiden Longevity Study (LLS).
Results
DNA methylation levels were measured in whole blood from the population-based KORA FF4 study (N = 1354) and LLS (N = 448), using the Illumina MethylationEPIC BeadChip and Illumina HumanMethylation450 array, respectively. We assessed associations between DNAm and intake of eight and four PUFAs in KORA and LLS, respectively …
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J Lange de Luna, A Nounu, S Neumeyer, L Sinke… - Clinical Epigenetics, 2024