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APOE4 has been hypothesized to increase Alzheimer’s disease risk by increasing neuroinflammation, though the specific neuroinflammatory pathways involved are unclear. Characterize cerebrospinal fluid (CSF) proteomic changes related to APOE4 copy number. We analyzed targeted proteomic data from ADNI CSF samples using a linear regression model adjusting for age, sex, and APOE4 copy number, and additional linear models also adjusting for AD clinical status or for CSF A, tau, or p-tau levels. False discovery rate was used to correct for multiple comparisons correction. Increasing APOE4 copy number was associated with a significant decrease in a CRP peptide level across all five models (q< 0.05 for each), and with significant increases in ALDOA, CH3L1 (YKL-40), and FABPH peptide levels (q< 0.05 for each) except when controlling for AD clinical status or …