作者
Eryi Wang, Xiaoyu Liu, Wei Tu, Danh C Do, Haiqiong Yu, Liteng Yang, Yufeng Zhou, Damo Xu, Shau‐Ku Huang, Pingchang Yang, Pixin Ran, Pei‐Song Gao, Zhigang Liu
发表日期
2019/9
期刊
Allergy
卷号
74
期号
9
页码范围
1675-1690
简介
Background
Environmental pollutants, which coexist with allergens, have been associated with the exacerbation of asthma. However, the underlying molecular mechanisms remain elusive. We sought to determine whether benzo(a)pyrene (BaP) co‐exposure with dermatophagoides group 1 allergen (Der f 1) can potentiate Der f 1‐induced asthma and its underlying mechanisms.
Methods
The effect of BaP was investigated in Der f 1‐induced mouse model of asthma, including airway hyper‐responsiveness, allergic inflammation, and epithelial‐derived cytokines. The impact of BaP on Der f 1‐induced airway epithelial cell oxidative stress (ROS) and cytokine release was further analyzed. The role of aryl hydrocarbon receptor (AhR) signaling in BaP‐promoted Der f 1‐induced ROS, cytokine production, and allergic inflammation was also investigated.
Results
Compared with Der f 1, BaP co‐exposure with Der f 1 …
学术搜索中的文章
E Wang, X Liu, W Tu, DC Do, H Yu, L Yang, Y Zhou… - Allergy, 2019