作者
Jheng-Yan Wu, Ya-Wen Tsai, Wan-Hsuan Hsu, Ting-Hui Liu, Po-Yu Huang, Min-Hsiang Chuang, Mei-Yuan Liu, Chih-Cheng Lai
发表日期
2023/7/8
来源
Critical Care
卷号
27
期号
1
页码范围
274
出版商
BioMed Central
简介
Background
This systematic review and meta-analysis aimed to investigate the clinical efficacy and safety of systemic corticosteroids in the treatment of patients with severe community-acquired pneumonia (sCAP).
Methods
A comprehensive search was conducted using the Medline, Embase, ClinicalTrials.gov, and Scopus databases for articles published until April 24, 2023. Only randomized controlled trials (RCTs) that assessed the clinical efficacy and safety of adjunctive corticosteroids for treating sCAP were included. The primary outcome was the 30-day all-cause mortality.
Results
A total of seven RCTs involving 1689 patients were included in this study. Overall, the study group had a lower mortality rate at day 30 than the control group (risk ratio [RR], 0.61; 95% CI 0.44 to 0.85; p < 0.01) with low heterogeneity (I2 = 0%, p = 0.42). Compared to the control group, the study group had a lower risk of the …
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