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Hosts infected with malicious software, so called malware, are ubiquitous in today's computer networks. The means whereby malware can infiltrate a network are manifold and range from exploiting of software vulnerabilities to tricking a user into executing malicious code. Monitoring and detection of all possible infection vectors is intractable in practice. Hence, we approach the problem of detecting malicious software at a later point when it initiates contact with its maintainer; a process referred to as "phoning home". In particular, we introduce Botzilla, a method for detection of malware communication, which proceeds by repetitively recording network traffic of malware in a controlled environment and generating network signatures from invariant content patterns. Experiments conducted at a large university network demonstrate the ability of Botzilla to accurately identify malware communication in network traffic with …