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With the decline in the number of new Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) infections, the World Health Organization announced the end of the SARS‐CoV‐2 pandemic. However, the repercussions of this viral pandemic may remain with us for a longer period of time, as it has remodeled the lives of humankind in many ways, including social and economic. Of course, its most important repercussions remain on the human health level. Long‐coronavirus disease (COVID) or post‐COVID is a state for which we do not have a concrete definition, a specific international classification of diseases Code, clear diagnostic tools, or well‐known effective cures as of yet. In this second article from the Intrinsic Factors behind long‐COVID Series, we try to link long‐COVID symptoms with their causes, starting from the nervous system. Extracellular vesicles (ECVs) play very complex and ramified roles …