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A better understanding of injury severity risk factors is fundamental to improving crash prediction and effective implementation of appropriate mitigation strategies. Traditional statistical models widely used in this regard have predefined correlation and intrinsic assumptions, which, if flouted, may yield biased predictions. The present study investigates the possibility of using the eXtreme Gradient Boosting (XGBoost) model compared with few traditional machine learning algorithms (logistic regression, random forest, and decision tree) for crash injury severity analysis. The data used in this study was obtained from the traffic safety department, ministry of transport (MOT) at Riyadh, KSA, and contains 13,546 motor vehicle collisions along 15 rural highways reported between January 2017 to December 2019. Empirical results obtained using k-fold (k = 10) for various performance metrics showed that the XGBoost …