作者
Jessica I Hoell, Erik Larsson, Simon Runge, Jeffrey D Nusbaum, Sujitha Duggimpudi, Thalia A Farazi, Markus Hafner, Arndt Borkhardt, Chris Sander, Thomas Tuschl
发表日期
2011/12
期刊
Nature structural & molecular biology
卷号
18
期号
12
页码范围
1428-1431
出版商
Nature Publishing Group US
简介
FUS, EWSR1 and TAF15, constituting the FET protein family, are abundant, highly conserved RNA-binding proteins with important roles in oncogenesis and neuronal disease, yet their RNA targets and recognition elements are unknown. Using PAR-CLIP, we defined global RNA targets for all human FET proteins and two ALS-causing human FUS mutants. FET members showed similar binding profiles, whereas FUS mutants showed a drastically altered binding pattern, consistent with changes in subcellular localization.
学术搜索中的文章
JI Hoell, E Larsson, S Runge, JD Nusbaum… - Nature structural & molecular biology, 2011