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Attending to the larger system components such as organizational design and management is not novel for ergonomists. In Europe, there has been a strong tradition to investigate ergonomic problems within a holistic, systems context. “Macroergonomics” builds upon this tradition by providing specific methods and tools that yield large-scale results. It is believed that meaningful and large-scale results are needed in today's competitive and turbulent work environments. Macroergonomics is defined, its history is uncovered and focus is given to a key methodology, macroergonomic analysis and design. Case studies are used to validate the method and illustrate that performance results in the 60–90% range can be expected.