作者
Joseph D Deak, D Angus Clark, Mengzhen Liu, Jonathan D Schaefer, Seon Kyeong Jang, C Emily Durbin, William G Iacono, Matt McGue, Scott Vrieze, Brian M Hicks
发表日期
2022/4
期刊
Addiction
卷号
117
期号
4
页码范围
1117-1127
简介
Background and Aims
Molecular genetic studies of alcohol and nicotine use have identified many genome‐wide association study (GWAS) loci. We measured associations between drinking and smoking polygenic scores (PGS) and trajectories of alcohol and nicotine use outcomes from late childhood to early adulthood, substance‐specific versus broader‐liability PGS effects, and if PGS performance varied for consumption versus problematic substance use.
Design, setting, participants and measurements
We fitted latent growth curve models with structured residuals to scores on measures of alcohol and nicotine use and problems from ages 14 to 34 years. We then estimated associations between the intercept (initial status) and slope (rate of change) parameters and PGSs for drinks per week (DPW), problematic alcohol use (PAU), cigarettes per day (CPD) and ever being a regular smoker (SMK), controlling for …
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