作者
Ross J Harris, Heather J Whitaker, Nick J Andrews, Felicity Aiano, Zahin Amin-Chowdhury, Jessica Flood, Ray Borrow, Ezra Linley, Shazaad Ahmad, Lorraine Stapley, Bassam Hallis, Gayatri Amirthalingam, Katja Höschler, Ben Parker, Alex Horsley, Timothy JG Brooks, Kevin E Brown, Mary E Ramsay, Shamez N Ladhani
发表日期
2021/5/1
期刊
Journal of Infection
卷号
82
期号
5
页码范围
162-169
出版商
WB Saunders
简介
Background
Antibody waning after SARS-CoV-2 infection may result in reduction in long-term immunity following natural infection and vaccination, and is therefore a major public health issue. We undertook prospective serosurveillance in a large cohort of healthy adults from the start of the epidemic in England.
Methods
Clinical and non-clinical healthcare workers were recruited across three English regions and tested monthly from March to November 2020 for SARS-CoV-2 spike (S) protein and nucleoprotein (N) antibodies using five different immunoassays. In positive individuals, antibody responses and long-term trends were modelled using mixed effects regression.
Findings
In total, 2246 individuals attended 12,247 visits and 264 were seropositive in ≥ 2 assays. Most seroconversions occurred between March and April 2020. The assays showed > 85% agreement for ever-positivity, although this changed …
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RJ Harris, HJ Whitaker, NJ Andrews, F Aiano… - Journal of Infection, 2021