作者
Vic J Verwaal, Serge van Ruth, Eelco de Bree, Gooike W van Slooten, Harm van Tinteren, Henk Boot, Frans AN Zoetmulder
发表日期
2003/10/15
期刊
Journal of clinical oncology
卷号
21
期号
20
页码范围
3737-3743
出版商
American Society of Clinical Oncology
简介
Purpose: To confirm the findings from uncontrolled studies that aggressive cytoreduction in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) is superior to standard treatment in patients with peritoneal carcinomatosis of colorectal cancer origin.
Patients and Methods: Between February 1998 and August 2001, 105 patients were randomly assigned to receive either standard treatment consisting of systemic chemotherapy (fluorouracil-leucovorin) with or without palliative surgery, or experimental therapy consisting of aggressive cytoreduction with HIPEC, followed by the same systemic chemotherapy regime. The primary end point was survival.
Results: After a median follow-up period of 21.6 months, the median survival was 12.6 months in the standard therapy arm and 22.3 months in the experimental therapy arm (log-rank test, P = .032). The treatment-related mortality in the aggressive …
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VJ Verwaal, S van Ruth, E de Bree, GW van Slooten… - Journal of clinical oncology, 2003