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Purpose: To retrospectively determine which of several computed tomographic (CT) colonography–based polyp measurements is most compatible with the linear measurement at optical colonoscopy and which is best for assessing change in polyp size.

Materials and Methods: This HIPAA-compliant study had institutional review board approval; informed consent was obtained. Prone and supine CT colonography with same-day optical colonoscopy was performed in 216 patients (147 men and 69 women; age range, 46–79 years; mean age, 59.2 years) with 338 polyps detected at CT colonography. Polyp size was measured with three linear measurements and two volume measurements. One linear measurement and one volume measurement were performed by using automated segmentation; remaining measurements were performed manually. Compatibility with linear size at optical colonoscopy and …