查看文章

The inverse gas chromatography study on the fluconazole drug surface was performed, and the net retention volumes, polar probes, and V_N of n-alkanes are determined at four temperatures over the range 318.15–333.15 K. The net retention values of n-alkanes were used to evaluate the London dispersive surface free energy γ_S^L by three different methods, namely, the Donnet–Park, Dorris–Gray, and Schultz methods. The γ_S^L values were found to increase from 318.15 to 323.15 K for all three methods and then decrease from 323.15 to 333.15 K. The γ_S^L values were found to be slightly higher in the Schultz method when compared to the results of the Donnet–Park and Dorris–Gray methods. The specific free energy values ΔG_a^S and the specific enthalpy ΔH_a^S values have been calculated using the V_N data of polar probes. The Guttmann Lewis acid–base parameters, K_a and K_b, were obtained using ΔH_a^S …