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The COVID-19 pandemic and the restrictions to minimize transmission of the virus affected the population worldwide. As a result of prolonged home confinement in Greece, changes in work schedules, disruptions of the educational process, the challenge of online learning, the constant need for self-protection, and the restrictions on social interaction, the family life was dramatically altered. In this study, sleep patterns of preschool children were recorded, and effects of screen time and diet were investigated in relation to quarantine due to COVID-19. Parents of 146 children provided data on their children’s night-time sleep habits, dietary habits, and screen time exposure. Children’s sleep problems were measured with the Children’s Sleep Questionnaire. Descriptive and qualitative analyses showed that most parents (54.1%) reported that children’s sleep habits changed during the imposed home confinement …