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Autonomous vehicles face tremendous challenges while interacting with human drivers in different kinds of scenarios. Developing control methods with safety guarantees while performing interactions with uncertainty is an ongoing research goal. In this paper, we present a real-time safe control framework using bi-level optimization with Control Barrier Function (CBF) that enables an autonomous ego vehicle to interact with human-driven cars in ramp merging scenarios with a consistent safety guarantee. In order to explicitly address motion uncertainty, we propose a novel extension of control barrier functions to a probabilistic setting with provable chance-constrained safety and analyze the feasibility of our control design. The formulated bi-level optimization framework entails first choosing the ego vehicle's optimal driving style in terms of safety and primary objective, and then minimally modifying a nominal controller …