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Dendritic cells (DC) play a crucial role in informing the adaptive immune system about infectious, innocuous or self antigens. Two developmentally distinct lineages of conventional DC, termed cDC1 and cDC2, have been described in mice and humans. cDC1 predominantly interact with CD8 T cells, while cDC2 interact with CD4 T cells to promote T helper (Th) and T regulatory cell responses. cDC2 present a high degree of phenotypic and functional heterogeneity in different tissues, suggesting that they adapt to diverse peripheral environments. Using high-dimensional proteomic and transcriptomic single-cell technologies, we could show that cDC2 exhibit unique signatures in different murine tissues at the steady state. Focusing on the developmental requirements of these subsets we could show that CD11b low cDC2, a population uniquely found in skin, required STAT6-and KLF4-dependent IL-13 signaling …