作者
Antonio Del Casale, Serena Sorice, Alessio Padovano, Maurizio Simmaco, Stefano Ferracuti, Dorian A Lamis, Chiara Rapinesi, Gabriele Sani, Paolo Girardi, Georgios D Kotzalidis, Maurizio Pompili
发表日期
2019/8/1
来源
Current neuropharmacology
卷号
17
期号
8
页码范围
710-736
出版商
Bentham Science Publishers
简介
Background
Obsessive-compulsive disorder (OCD) is associated with affective and cognitive symptoms causing personal distress and reduced global functioning. These have considerable societal costs due to healthcare service utilization.
Objective
Our aim was to assess the efficacy of pharmacological interventions in OCD and clinical guidelines, providing a comprehensive overview of this field.
Methods
We searched the PubMed database for papers dealing with drug treatment of OCD, with a specific focus on clinical guidelines, treatments with antidepressants, antipsychotics, mood stabilizers, off-label medications, and pharmacogenomics.
Results
Prolonged administration of selective serotonin reuptake inhibitors (SSRIs) is most effective. Better results can be obtained with a SSRI combined with cognitive behavioral therapy (CBT) or the similarly oriented exposure and response prevention (ERP). Refractory …
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A Del Casale, S Sorice, A Padovano, M Simmaco… - Current neuropharmacology, 2019