作者
Christopher Mogg, Christopher Bonner, Li Wang, Johann Schernthaner, Myron Smith, Darrell Desveaux, Rajagopal Subramaniam
发表日期
2019/6/25
期刊
MBio
卷号
10
期号
3
页码范围
10.1128/mbio. 00792-19
出版商
American Society for Microbiology
简介
Antofine, a phenanthroindolizidine alkaloid, is a bioactive natural product isolated from milkweeds that exhibits numerous biological activities, including anticancer, antimicrobial, antiviral, and anti-inflammatory properties. However, the direct targets and mode of action of antofine have not been determined. In this report, we show that antofine displays antifungal properties against the phytopathogen Fusarium graminearum, the cause of Fusarium head blight disease (FHB). FHB does devastating damage to agriculture, causing billions of dollars in economic losses annually. We therefore sought to understand the mode of action of antofine in F. graminearum using insights from yeast chemical genomic screens. We used haploinsufficiency profiling (HIP) to identify putative targets of antofine in yeast and identified three candidate targets, two of which had homologs in F. graminearum. The Fusarium homologues of two …
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C Mogg, C Bonner, L Wang, J Schernthaner, M Smith… - MBio, 2019