作者
Takuya Uehata, Naohisa Tomosugi, Tatsuya Shoji, Yusuke Sakaguchi, Akira Suzuki, Tetsuya Kaneko, Noriyuki Okada, Ryohei Yamamoto, Yasuyuki Nagasawa, Kiminori Kato, Yoshitaka Isaka, Hiromi Rakugi, Yoshiharu Tsubakihara
发表日期
2012/3/1
期刊
Nephrology Dialysis Transplantation
卷号
27
期号
3
页码范围
1076-1083
出版商
Oxford University Press
简介
Background
Hepcidin is a central regulator of iron homeostasis. Increased hepcidin concentrations could cause iron-restricted erythropoiesis in chronic kidney disease (CKD)-associated anemia. This cross-sectional observational study was conducted to evaluate the association between hepcidin and CKD-associated anemia in non-dialysis CKD patients.
Methods
A total of 505 non-dialysis CKD patients not treated with parenteral iron were recruited, and serum hepcidin-25 levels were measured by liquid chromatography tandem mass spectrometry. Multiple linear regression analysis was used to examine the relationship between hepcidin and glomerular filtration rate (GFR) and the relationship between hemoglobin concentration and predictors including the hepcidin level.
Results
The median hepcidin level among the 505 CKD patients was 15.4 ng/mL …
学术搜索中的文章
T Uehata, N Tomosugi, T Shoji, Y Sakaguchi, A Suzuki… - Nephrology Dialysis Transplantation, 2012