作者
Josephine Cruzat, Ruben Herzog, Pavel Prado, Yonatan Sanz-Perl, Raul Gonzalez-Gomez, Sebastian Moguilner, Morten L Kringelbach, Gustavo Deco, Enzo Tagliazucchi, Agustín Ibañez
发表日期
2023/3/1
期刊
Journal of Neuroscience
卷号
43
期号
9
页码范围
1643-1656
出版商
Society for Neuroscience
简介
Healthy brain dynamics can be understood as the emergence of a complex system far from thermodynamic equilibrium. Brain dynamics are temporally irreversible and thus establish a preferred direction in time (i.e., arrow of time). However, little is known about how the time-reversal symmetry of spontaneous brain activity is affected by Alzheimer's disease (AD). We hypothesized that the level of irreversibility would be compromised in AD, signaling a fundamental shift in the collective properties of brain activity toward equilibrium dynamics. We investigated the irreversibility from resting-state fMRI and EEG data in male and female human patients with AD and elderly healthy control subjects (HCs). We quantified the level of irreversibility and, thus, proximity to nonequilibrium dynamics by comparing forward and backward time series through time-shifted correlations. AD was associated with a breakdown of temporal …
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J Cruzat, R Herzog, P Prado, Y Sanz-Perl… - Journal of Neuroscience, 2023