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The fractional amplitude of low-frequency fluctuations (fALFF) has been widely used as potential clinical biomarkers for resting-state functional-magnetic-resonance-imaging-based schizophrenia diagnosis. How-ever, previous studies usually measure the fALFF with specific bands from 0.01 to 0.08 Hz, which cannot fully delineate the complex variations of spontaneous fluctuations in the resting-state brain. In addition, fALFF data are intrinsically constrained by the brain structure, but most of the traditional methods have not consider it in feature selection. For addressing these problems, we propose a model to classify schizophrenia in multifrequency bands with tree-guided group sparse learning. In detail, we first acquire the fALFF data in multifrequency bands (i.e., slow-5: 0.01-0.027 Hz, slow-4: 0.027-0.073 Hz, slow-3: 0.073-0.198 Hz, and slow-2: 0.198-0.25 Hz). Then, we divide the whole brain into different …