作者
Reitze N Rodseth, Bruce M Biccard, Rong Chu, Giovana A Lurati Buse, Lehana Thabane, Ameet Bakhai, Daniel Bolliger, Lucio Cagini, Thomas J Cahill, Daniela Cardinale, Carol PW Chong, Miłosław Cnotliwy, Salvatore Di Somma, René Fahrner, Wen K Lim, Elisabeth Mahla, Yannick Le Manach, Ramaswamy Manikandan, Wook B Pyun, Sriram Rajagopalan, Milan Radovic, Robert C Schutt, Daniel I Sessler, Stuart Suttie, Thuvaraha Vanniyasingam, Marek Waliszek, PJ Devereaux
发表日期
2013/8/1
来源
Anesthesiology
卷号
119
期号
2
页码范围
270-283
简介
Background
It is unclear whether postoperative B-type natriuretic peptides (i.e., BNP and N-terminal proBNP) can predict cardiovascular complications in noncardiac surgery.
Methods
The authors undertook a systematic review and individual patient data meta-analysis to determine whether postoperative BNPs predict postoperative cardiovascular complications at 30 and 180 days or more.
Results
The authors identified 18 eligible studies (n = 2,051). For the primary outcome of 30-day mortality or nonfatal myocardial infarction, BNP of 245 pg/ml had an area under the curve of 0.71 (95% CI, 0.64–0.78), and N-terminal proBNP of 718 pg/ml had an area under the curve of 0.80 (95% CI, 0.77–0.84). These thresholds independently predicted 30-day mortality or nonfatal myocardial infarction (adjusted odds ratio [AOR] 4.5; 95% CI, 2.74–7.4; P < 0.001), mortality …
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RN Rodseth, BM Biccard, R Chu, GA Lurati Buse… - Anesthesiology, 2013