作者
Masahiro Kanai, Shea J Andrews, Mattia Cordioli, Christine Stevens, Benjamin M Neale, Mark Daly, Andrea Ganna, Gita A Pathak, Akiko Iwasaki, Juha Karjalainen, Juha Mehtonen, Matti Pirinen, Karolina Chwialkowska, Amy Trankiem, Mary K Balaconis, Kumar Veerapen, Brooke N Wolford, Hajar Fauzan Ahmad, Shea Andrews, Kathrin Aprile von Hohenstaufen Puoti, Cindy Boer, Palwende R Boua, Guillaume Butler-Laporte, Carmen L Cadilla, Karolina Chwiałkowska, Francesca Colombo, Venceslas Douillard, Nicole Dueker, Atanu Kumar Dutta, Yasser M El-Sherbiny, Madonna M Eltoukhy, Sahar Esmaeeli, Annika Faucon, Marie-Julie Fave, Israel Fernández Cadenas, Margherita Francescatto, Laurent Francioli, Lude Franke, Macarena Fuentes, Rocío Gallego Durán, David Gómez Cabrero, Emi N Harry, Philip Jansen, József L Szentpéteri, Elżbieta Kaja, Masahiro Kanai, Chloe Kirk, Athanasios Kousathanas, Jose E Krieger, Sanjay K Patel, Audrey Lemaçon, Sophie Limou, Pietro Lió, Eirini Marouli, Minttu M Marttila, Carolina Medina-Gómez, Yael Michaeli, Isabelle Migeotte, Soumyajit Mondal, Andrés Moreno-Estrada, Leire Moya, Tomoko Nakanishi, Jamal Nasir, Dorote Pasko, Nathaniel M Pearson, Alexandre C Pereira, James Priest, Vid Prijatelj, Ivana Prokić, Alexander Teumer, Réka Várnai, Manuel Romero-Gómez, Christina Roos, Jeffrey Rosenfeld, Li Ruolin, Eva C Schulte, Claudia Schurmann, Bahar Sedaghati-khayat, Doaa Shaheen, Ilangumaran Shivanathan, Csilla Sipeky, Zhou Sirui, Pasquale Striano, Yosuke Tanigawa, Alicia Utrilla Remesal, Nirmal Vadgama, Costanza L Vallerga, Sander van der Laan, Ricardo A Verdugo, Qingbo S Wang, Zhou Wei, Ummu Afeera Zainulabid, Ruth N Zárate, Adam Auton, Janie F Shelton, Anjali J Shastri, Catherine H Weldon, Teresa Filshtein-Sonmez, Daniella Coker, Antony Symons, Stella Aslibekyan, Jared O’Connell, Chelsea Ye, Alexander S Hatoum, Arpana Agrawal, Ryan Bogdan, Sarah MC Colbert, Wesley K Thompson, Chun Chieh Fan, Emma C Johnson, Lyudmila Niazyan, Mher Davidyants, Arsen Arakelyan, Diana Avetyan, Makhabbat Bekbossynova, Ainur Tauekelova, Mukhtar Tuleutayev, Aliya Sailybayeva, Yerlan Ramankulov, Elena Zholdybayeva, Jarkyn Dzharmukhanov, Kuat Kassymbek, Tatyana Tsechoeva, Gulsimzhan Turebayeva, Zauresh Smagulova, Timur Muratov, Sadyk Khamitov, Alex SF Kwong, Nicholas J Timpson, Mari EK Niemi, Souad Rahmouni, Julien Guntz, Yves Beguin, Mattia Cordioli, Sara Pigazzini, Lindokuhle Nkambule, Michel Georges, Michel Moutschen, Benoit Misset, Gilles Darcis, Stéphanie Gofflot, Youssef Bouysran, Adeline Busson, Xavier Peyrassol, Françoise Wilkin, Bruno Pichon, Guillaume Smits, Isabelle Vandernoot, Jean-Christophe Goffard, Nicky Tiembe
发表日期
2023/9/7
期刊
Nature
卷号
621
期号
7977
页码范围
E7-E26
出版商
Springer Science and Business Media LLC
简介
Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1, 2. Here we present a second updated genome-wide association study (GWAS) on COVID-19 severity and infection susceptibility to SARS-CoV-2 from the COVID-19 Host Genetic Initiative (data release 7). We performed a meta-analysis of up to 219,692 cases and over 3 million controls, identifying 51 distinct genome-wide significant loci—adding 28 loci from the previous data release 2. The increased number of candidate genes at the identified loci helped to map three major biological pathways that are involved in susceptibility and severity: viral entry, airway defence in mucus and type I interferon. We conducted a meta-analysis for 3 phenotypes across 82 studies from 35 countries, including 36 studies …
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