作者
Thushan I de Silva, Guihai Liu, Benjamin B Lindsey, Danning Dong, Shona C Moore, Nienyun Sharon Hsu, Dhruv Shah, Dannielle Wellington, Alexander J Mentzer, Adrienn Angyal, Rebecca Brown, Matthew D Parker, Zixi Ying, Xuan Yao, Lance Turtle, Susanna Dunachie, David M Aanensen, Khalil Abudahab, Helen Adams, Alexander Adams, Safiah Afifi, Dinesh Aggarwal, Shazaad SY Ahmad, Louise Aigrain, Adela Alcolea-Medina, Nabil-Fareed Alikhan, Elias Allara, Roberto Amato, Tara Annett, Stephen Aplin, Cristina V Ariani, Hibo Asad, Amy Ash, Paula Ashfield, Fiona Ashford, Laura Atkinson, Stephen W Attwood, Cressida Auckland, Alp Aydin, David J Baker, Paul Baker, Carlos E Balcazar, Jonathan Ball, Jeffrey C Barrett, Magdalena Barrow, Edward Barton, Matthew Bashton, Andrew R Bassett, Rahul Batra, Chris Baxter, Nadua Bayzid, Charlotte Beaver, Angela H Beckett, Shaun M Beckwith, Luke Bedford, Robert Beer, Andrew Beggs, Katherine L Bellis, Louise Berry, Beatrice Bertolusso, Angus Best, Emma Betteridge, David Bibby, Kelly Bicknell, Debbie Binns, Alec Birchley, Paul W Bird, Chloe Bishop, Rachel Blacow, Victoria Blakey, Beth Blane, Frances Bolt, James Bonfield, Stephen Bonner, David Bonsall, Tim Boswell, Andrew Bosworth, Yann Bourgeois, Olivia Boyd, Declan T Bradley, Cassie Breen, Catherine Bresner, Judith Breuer, Stephen Bridgett, Iraad F Bronner, Ellena Brooks, Alice Broos, Julianne R Brown, Giselda Bucca, Sarah L Buchan, David Buck, Matthew Bull, Phillipa J Burns, Shirelle Burton-Fanning, Timothy Byaruhanga, Matthew Byott, Sharon Campbell, Alessandro M Carabelli, James S Cargill, Matthew Carlile, Silvia F Carvalho, Anna Casey, Anibolina Castigador, Jana Catalan, Vicki Chalker, Nicola J Chaloner, Meera Chand, Joseph G Chappell, Themoula Charalampous, Wendy Chatterton, Yasmin Chaudhry, Carol M Churcher, Gemma Clark, Phillip Clarke, Benjamin J Cogger, Kevin Cole, Jennifer Collins, Rachel Colquhoun, Thomas R Connor, Kate F Cook, Jason Coombes, Sally Corden, Claire Cormie, Nicholas Cortes, Marius Cotic, Seb Cotton, Simon Cottrell, Lindsay Coupland, MacGregor Cox, Alison Cox, Noel Craine, Liam Crawford, Aidan Cross, Matthew R Crown, Dorian Crudgington, Nicola Cumley, Tanya Curran, Martin D Curran, Ana da Silva Filipe, Gavin Dabrera, Alistair C Darby, Rose K Davidson, Alisha Davies, Robert M Davies, Thomas Davis, Daniela de Angelis, Elen De Lacy, Leonardo de Oliveira Martins, Johnny Debebe, Rebecca Denton-Smith
发表日期
2021/11/19
期刊
Iscience
卷号
24
期号
11
出版商
Elsevier
简介
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as …
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TI de Silva, G Liu, BB Lindsey, D Dong, SC Moore… - Iscience, 2021