作者
Yogesh NV Reddy, Thomas P Olson, Masaru Obokata, Vojtech Melenovsky, Barry A Borlaug
发表日期
2018/8
期刊
JACC: Heart Failure
卷号
6
期号
8
页码范围
665-675
出版商
American College of Cardiology Foundation
简介
Objectives
This study sought to define the invasive hemodynamic correlates of peak oxygen consumption (Vo2) in both supine and upright exercise in heart failure with preserved ejection fraction (HFpEF) and evaluate its diagnostic role as a method to discriminate HFpEF from noncardiac etiologies of dyspnea (NCD).
Background
Peak Vo2 is depressed in patients with HFpEF. The hemodynamic correlates of reduced peak Vo2 and its role in the clinical evaluation of HFpEF are unclear.
Methods
Consecutive patients with dyspnea and normal EF (N = 206) undergoing both noninvasive upright and invasive supine cardiopulmonary exercise testing were examined. Patients with invasively verified HFpEF were compared with those with NCD.
Results
Compared with NCD (n = 72), HFpEF patients (n = 134) displayed lower peak Vo2 during upright and supine exercise. Left heart filling pressures during exercise were …
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YNV Reddy, TP Olson, M Obokata, V Melenovsky… - JACC: Heart Failure, 2018