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The wide usage of tetracyclines in livestock farming may result in drug residues in foods. Therefore, it is necessary to develop reliable methods for the determination of tetracyclines in foods.

A dispersive liquid-liquid microextraction (DLLME) combined with HPLC method was developed for the analysis of six tetracyclines in eggs and chicken.

After deproteinization, tetracyclines in acidic solutions were concentrated by vortex-assisted DLLME. After the addition of NaCl (35% for eggs and 20% for chicken), a mixture of ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate and ethyl acetate (300 μL–50 μL for eggs and 200 μL–60 μL for chicken) was used as the extractant. After centrifugation, the extract was collected for HPLC analysis.

The developed method showed good linear …