作者
Oon Tek Ng, Oliver Laeyendecker, Andrew D Redd, Supriya Munshaw, Mary K Grabowski, Agnes C Paquet, Mark C Evans, Mojgan Haddad, Wei Huang, Merlin L Robb, Steven J Reynolds, Ronald H Gray, Maria J Wawer, David Serwadda, Susan H Eshleman, Thomas C Quinn
发表日期
2014/1/1
期刊
The Journal of infectious diseases
卷号
209
期号
1
页码范围
66-73
出版商
Oxford University Press
简介
Background. Determinants of intersubtype differences in human immunodeficiency virus type 1 (HIV-1) clinical disease progression remain unknown.
Methods. HIV-1 subtype was independently determined for 5 separate genomic regions in 396 HIV-1 seroconverters from Rakai, Uganda, using a multiregion hybridization assay. Replication capacities (RC) in samples from a subset of 145 of these subjects were determined. HIV-1 genomic regions and pol RC were examined for association with disease progression. Amino acid polymorphisms were examined for association with pol RC.
Results. In multivariate analyses, the hazard for progression to the composite end point (defined as a CD4+ T-cell count <250 cells/mm3, antiretroviral therapy initiation, or death) among patients with subtype D pol infection was 2.4 times the hazard for those …
学术搜索中的文章
OT Ng, O Laeyendecker, AD Redd, S Munshaw… - The Journal of infectious diseases, 2014