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The world has been faced with the coronavirus disease 2019 (COVID-19) pandemic. Several antiviral medications have been granted emergency use authorization for treatment of patients with COVID-19 including Paxlovid (nirmatrelvir and ritonavir)(Pfizer. Location, New York City, NY) and Lagevrio (molnupiravir)(Merck, Kenilworth, NJ). 1 There are no data on the use of these medications in patients with inflammatory bowel disease (IBD) who develop a COVID-19 infection. This report compares the outcomes of patients with IBD who received antiviral medications for COVID-19 with those who did not and with non-IBD patients who received antiviral medications. A retrospective cohort study was performed using TriNetX (Cambridge, MA) which provides real-time access to deidentified electronic health records of more than 78 million patients. A real-time search and analysis of the TriNetX platform was conducted …