作者
Rainer Lehmann, Holger Franken, Sascha Dammeier, Lars Rosenbaum, Konstantinos Kantartzis, Andreas Peter, Andreas Zell, Patrick Adam, Jia Li, Guowang Xu, Alfred Königsrainer, Jürgen Machann, Fritz Schick, Martin Hrabé de Angelis, Matthias Schwab, Harald Staiger, Erwin Schleicher, Amalia Gastaldelli, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan
发表日期
2013/8/1
期刊
Diabetes care
卷号
36
期号
8
页码范围
2331-2338
出版商
American Diabetes Association
简介
OBJECTIVE
Nonalcoholic fatty liver (NAFL) is thought to contribute to insulin resistance and its metabolic complications. However, some individuals with NAFL remain insulin sensitive. Mechanisms involved in the susceptibility to develop insulin resistance in humans with NAFL are largely unknown. We investigated circulating markers and mechanisms of a metabolically benign and malignant NAFL by applying a metabolomic approach.
RESEARCH DESIGN AND METHODS
A total of 265 metabolites were analyzed before and after a 9-month lifestyle intervention in plasma from 20 insulin-sensitive and 20 insulin-resistant subjects with NAFL. The relevant plasma metabolites were then tested for relationships with insulin sensitivity in 17 subjects without NAFL and in plasma from 29 subjects with liver tissue samples.
RESULTS
The best separation of the insulin …
学术搜索中的文章
R Lehmann, H Franken, S Dammeier, L Rosenbaum… - Diabetes care, 2013