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Early studies projected potential societal, economic and environmental benefits by the widespread deployment of Autonomous and Connected Transport (ACT) promising a significant reduction of transport costs and improvement in road safety. An effective way of assessing ACT impact is via simulations, where results are largely affected by the scenarios defining the ACT development. However, modelled scenarios are very diverse due to the huge uncertainty in ACT development and deployment. This chapter aims to shed light on the different ACT simulation scenarios and sustainability aspects that should be considered while developing or reporting the simulation results. To this end, this chapter discusses the various simulation approaches, what the required (or the typically utilised) pipelines are, and how some components are more important or less important than in ‘classic’modelling and simulation …