作者
Jörg Müller, Gregor K Wenning, Marc Verny, Ann McKee, K Ray Chaudhuri, Kurt Jellinger, Werner Poewe, Irene Litvan
发表日期
2001/2/1
期刊
Archives of neurology
卷号
58
期号
2
页码范围
259-264
出版商
American Medical Association
简介
Background
Dysarthria and dysphagia are known to occur in parkinsonian syndromes such as Parkinson disease (PD), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). Differences in the evolution of these symptoms have not been studied systematically in postmortem-confirmed cases.
Objective
To study differences in the evolution of dysarthria and dysphagia in postmortem-confirmed parkinsonian disorders.
Patients and Methods
Eighty-three pathologically confirmed cases (PD, n = 17; MSA, n = 15; DLB, n = 14; PSP, n = 24; and CBD, n = 13) formed the basis for a multicenter clinicopathological study organized by the National Institute of Neurological Disorders and Stroke, Bethesda, Md. Cases with enough clinicopathological documentation for the purpose of the study were selected from research and neuropathological …
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