作者
Dag Aarsland, Lucia Batzu, Glenda M Halliday, Gert J Geurtsen, Clive Ballard, K Ray Chaudhuri, Daniel Weintraub
发表日期
2021/7/1
来源
Nature Reviews Disease Primers
卷号
7
期号
1
页码范围
1-21
出版商
Nature Publishing Group
简介
Parkinson disease (PD) is the second most common neurodegenerative disorder, affecting> 1% of the population≥ 65 years of age and with a prevalence set to double by 2030. In addition to the defining motor symptoms of PD, multiple non-motor symptoms occur; among them, cognitive impairment is common and can potentially occur at any disease stage. Cognitive decline is usually slow and insidious, but rapid in some cases. Recently, the focus has been on the early cognitive changes, where executive and visuospatial impairments are typical and can be accompanied by memory impairment, increasing the risk for early progression to dementia. Other risk factors for early progression to dementia include visual hallucinations, older age and biomarker changes such as cortical atrophy, as well as Alzheimer-type changes on functional imaging and in cerebrospinal fluid, and slowing and frequency variation on …
引用总数
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D Aarsland, L Batzu, GM Halliday, GJ Geurtsen… - Nature Reviews Disease Primers, 2021