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Massive multiple-input multiple-output (MIMO) is a crucial technology platform for the fifth-generation of cellular systems (5G). However, massive MIMO systems are affected by pilot contamination, which influences the data rate of the system. This contamination is caused by the non-orthogonality of the pilot sequences transmitted by users in a cell similar to the neighboring cells. The current study proposes a channel-estimation scheme that employs comprehensive knowledge of large-scale gained by applying an orthogonal pilot reuse sequence to eliminate pilot contamination in edge users with reduced channel quality based on the approximation of large-scale fading, and the performance of this scheme is evaluated using the maximum ratio transmission and zero-forcing precoding techniques. Largely interfering users in neighboring cells are established based on an estimation of large-scale fading, and these …