作者
Pedro Mario Pan, João R Sato, Marie-Laure Paillère Martinot, Jean-Luc Martinot, Eric Artiges, Jani Penttilä, Yvonne Grimmer, Betteke M van Noort, Andreas Becker, Tobias Banaschewski, Arun LW Bokde, Sylvane Desrivières, Herta Flor, Hugh Garavan, Bernd Ittermann, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H Fröhner, Robert Whelan, Gunter Schumann, Margaret L Westwater, Christian Grillon, Hugo Cogo-Moreira, Argyris Stringaris, Monique Ernst, IMAGEN Consortium
发表日期
2022/7/1
期刊
American Journal of Psychiatry
卷号
179
期号
7
页码范围
470-481
出版商
American Psychiatric Association
简介
Objective
Research in adolescent depression has found aberrant intrinsic functional connectivity (iFC) among the ventral striatum (VS) and several brain regions implicated in reward processing. The present study probes this question by taking advantage of the availability of data from a large youth cohort, the IMAGEN Consortium.
Methods
iFC data from 303 adolescents (48% of them female) were used to examine associations of VS connectivity at baseline (at age 14) with depressive disorders at baseline and at 2-year (N=250) and 4-year (N=219) follow-ups. Eleven regions of interest, key nodes of the reward system, were used to probe the reward network and calculate the connectivity strength of the VS within this network (VS connectivityrw). The main analyses assessed associations of VS connectivityrw with depressive disorders, anhedonia, and low mood using logistic regression. Autoregressive models …
学术搜索中的文章
PM Pan, JR Sato, ML Paillère Martinot, JL Martinot… - American Journal of Psychiatry, 2022