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Aim: To determine the effects of metformin alone versus metformin and magnesium supplemented diet on insulin sensitivity and insulin receptor in type 2 diabetic Sprague Dawley rats.

Material and Methods: Total of 24 Sprague dawley rats (Four groups of six rats each were used for this study, namely: a. Group 1: Normal control rats (CONTROL) given distilled water for 4 weeks; b. Group 2: Diabetic untreated control rats (DU) given distilled water for 4 weeks; c. Group 3: Metformin treated diabetic rats (DM), orally given 100mg/kg body weight for 4 weeks; d. Group 4: Metformin treated diabetic rats (DMM), orally given 100mg/kg body weight with 2000mg/kg body weight magnesium supplemented feed for 4 weeks). Measured data was analyzed statistically.