作者
Anak AR Sudewi, Ni M Susilawathi, Bayu K Mahardika, Agung N Mahendra, Made Pharmawati, Mark A Phuong, Gusti N Mahardika
发表日期
2019/11/6
期刊
ACS omega
卷号
4
期号
21
页码范围
19483-19490
出版商
American Chemical Society
简介
Many conotoxins, natural peptides of marine cone snails, have been identified to target neurons. Here, we provide data on pharmacological families of the conotoxins of 11 species of cone snails collected in Bali. The identified definitive pharmacological families possibly targeting neuronal tissues were α (alpha), ι (iota), κ (kappa), and ρ (rho). These classes shall target nicotinic acetylcholine receptors, voltage-gated Na channels, voltage-gated K channels, and α1-adrenoceptors, respectively. The VI/VII-O3 conotoxins might be prospected as an inhibitor of N-methyl-d-aspartate. Con-ikot-ikot could be applied as an α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor blocker medicine. The definitive pharmacology classes of conotoxins as well as those yet to be elucidated need to be further established and verified.
引用总数
2020202120222023202415411