作者
Sarah J Lewis, Mike Gardner, Julian Higgins, Jeff MP Holly, Tom R Gaunt, Claire M Perks, Suzanne D Turner, Sabina Rinaldi, Steve Thomas, Sean Harrison, Rosie J Lennon, Vanessa Tan, Cath Borwick, Pauline Emmett, Mona Jeffreys, Kate Northstone, Giota Mitrou, Martin Wiseman, Rachel Thompson, Richard M Martin
发表日期
2017/11/1
期刊
Cancer Epidemiology, Biomarkers & Prevention
卷号
26
期号
11
页码范围
1667-1675
出版商
American Association for Cancer Research
简介
Background: Human, animal, and cell experimental studies; human biomarker studies; and genetic studies complement epidemiologic findings and can offer insights into biological plausibility and pathways between exposure and disease, but methods for synthesizing such studies are lacking. We, therefore, developed a methodology for identifying mechanisms and carrying out systematic reviews of mechanistic studies that underpin exposure–cancer associations.
Methods: A multidisciplinary team with expertise in informatics, statistics, epidemiology, systematic reviews, cancer biology, and nutrition was assembled. Five 1-day workshops were held to brainstorm ideas; in the intervening periods we carried out searches and applied our methods to a case study to test our ideas.
Results: We have developed a two-stage framework, the first stage of which is designed to identify …
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SJ Lewis, M Gardner, J Higgins, JMP Holly, TR Gaunt… - Cancer Epidemiology, Biomarkers & Prevention, 2017